01
Modulation & Design
Protein–Protein Interactions
Developing inhibitors and stabilizers of protein-protein interactions involved in cardiovascular processes and pain pathways.
CardiovascularPainInhibitorsStabilizers
CSIC Research Excellence
Peptidomimetics'
Group
Leading Spanish research group in peptidomimetics, advancing bioactive molecules for biomedical applications through molecular modeling and synthesis.
Ion Channel ModulatorsProtein-Protein InteractionsDrug Design
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Supported by Leading Research Funding Institutions
Our research is enabled by generous support from national and international funding agencies, advancing scientific discovery and innovation.
About the Group
Pioneering Molecular Solutions for Biomedical Challenges
We are a leading Spanish research group specializing in peptidomimetics, combining strong expertise in molecular modeling with both solution and solid-phase synthesis of peptides and small molecules.
Our mission is to advance knowledge on bioactive molecules for biomedical applications, developing novel prototypes for specific therapeutic areas while creating versatile molecular scaffolds and methodologies for Medicinal and Biological Chemistry.
40+Years
200+Publications
6Patents
Instituto de Química MédicaCSIC — Madrid, Spain
Research Focus
Main Research Lines
Our work spans three interconnected research areas, combining computational and experimental approaches to develop novel therapeutic solutions.
02
Therapeutic Targets
Ion Channel Modulators
TRP channels (TRPM8, TRPA1, TRPV1) for inflammatory and neuropathic pain; sodium and potassium channels (Nav1.5, Kv1.5, Kv4.3) for arrhythmias; non-steroidal MR antagonists for cardiovascular applications.
TRPM8PainArrhythmiasVoltage-gated Channels
03
Transversal Research
Tools & Methodologies
Molecular modeling, virtual screening, computational study of mutations, development of versatile synthetic methodologies, and generation of secondary-structure mimetics.
ModelingVirtual ScreeningSynthesisMimetics
Funded Research
Recent Projects
Our research is supported by national and international funding agencies, enabling cutting-edge investigations across multiple therapeutic areas.
Research Output
Featured Publications
Selected peer-reviewed articles from our recent research in peptidomimetics and bioactive molecule design.
200+Publications
15Years
25
Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives
C. Martín-Escura, M. A. Bonache, A. Medina-Peris, T. Voets, A. Ferrer-Montiel, A. Fernández-Carvajal, R. González-Muñiz
Explor. Drug Sci.·2025
25
Natural modulators of abscisic acid signaling: insights into polyphenol-based antagonists and their role in ABA receptor regulation
J. Merino, M. Rivera-Moreno, M. Bono, D. Núñez-Villanueva, et al.
Plant Physiol. Biochem.·2025
25
Covalent template-directed synthesis: a powerful tool for the construction of complex molecules
P. Bolgar, M. Dhiman, D. Núñez-Villanueva, C.A. Hunter
Chem. Rev.·2025
24
Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome
F. M. Cruz, A. Macías, A. I. Moreno-Manuel, et al.
Circ. Res.·2024
Translational Science
Innovation & Patents
Bridging fundamental research with real-world applications through intellectual property protection and technology transfer.
Impact StoryLicensed & In Exploitation
Heterocyclic Compounds as TRPM8 Channel Antagonists and Uses Thereof
A. Ferrer Montiel, A. Fernández-Carvajal, R. de la Torre, R. González-Muñiz, M. J. Pérez de Vega, M. A. Bonache
A compound from this patent has been developed as a neurocosmetic ingredient for alleviating chemotherapy-induced peripheral neuropathy.
Patent Code
P201530960, PCT/ES2016/070483 (WO 2017005950)
Status
Licensed to Alodia Farmacéutica SL (23/7/2017) — In exploitation
Cardiovascular
Peptides for the Treatment of Heart Diseases
E. Delpón Mosquera, R. Caballero Collado, T. Crespo García, A. Cámara Checa, J. Rapún Jiménez, J. Tamargo Menéndez, R. González Muñiz, D. Núñez Villanueva, M. J. Pérez De Vega, C. Cuadros Higueras, P. Esteban Arderius, D. Filgueiras Rama, J. Jalife Sacal
PCT/ES2024/07058625/09/2024
UCM, CSIC, CNIC
Antiviral
Peptidomimetics with Antiviral Activity
R. González Muñiz, M. Martín Martínez, M.A. Bonache de Marcos, S. Algar Lizana, U. Garaigorta de Dios, P. Gastaminza Landart, P. Bueno Fernández, V. Castro Illana
EP2338280802/08/2023
CSIC
Therapeutics
Peptide Derived from GSE24.2 and Uses Thereof
P. Guillen Morales, R. Perona Abellon, L. Sastre Garzón, B. Fernández Varas, M. Gutierrez-Rodríguez, M. Martín-Martínez, R. Guerrero López
PCT/ES2023/07017217/03/2023
CSIC, UAM, CIBER
Licensed to Mediczen Global SL
Antioxidant
Compounds with Antioxidant Activity and Uses Thereof
R. González-Muñiz, M.J. Pérez de Vega, M. Miguel, S. Moreno, B. Sabater-Muñoz
P201630362, PCT/ES2017/070179 (WO 2017168024)28/03/2017
CSIC
MTA signed with NOREL SA (2022)
Cardiovascular
Modulating Compounds of KChIP2 and Their Use for the Treatment of Cardiovascular Pathologies
M. Gutiérrez-Rodríguez, M. C. Valenzuela, M. Martín-Martínez, C. Delgado Canencia, J. R. Naranjo
PCT/EP2019/08343203/12/2019
CSIC, UAM
Our People
Meet the Team
A dedicated group of researchers combining expertise in medicinal chemistry, molecular modeling, and synthetic methodologies.
Staff Personnel
Research Associates & Students
MAD
Mario Abellán Dumont
PhD Student
CCH
Carlos Cuadros Higueras
PhD Student
PMS
Pedro Martínez Salas
PhD Student
CRB
Clara Rodríguez Blanco
CSIC Youth Employment
JRC
Juan Remiro Chacón
PhD Student
SOR
Sandra Ortiz Rovira
Master Student
ALG
Alba López García
Undergraduate Intern
Work With Us
Join Our Research
We welcome inquiries from prospective PhD students, postdoctoral researchers, and potential collaborators interested in peptidomimetics and bioactive molecule design.
1
Graduate, PhD and Master’s Opportunities
PhD and Master’s positions in medicinal chemistry and molecular design
2
Postdoctoral Fellowships
Opportunities for experienced researchers in peptide synthesis
3
Scientific Collaborations
Partnerships with academic and industry research groups
4
Technology Transfer
Licensing and translational research partnerships
Get in Touch
RGM
Rosario González Muñiz
CSIC Research Professor
iqmg313@iqm.csic.es
MMM
Mercedes Martín Martínez
CSIC Tenured Scientist
mmartin@iqm.csic.es
DNV
Diego Núñez Villanueva
CSIC Tenured Scientist
diegonunez@iqm.csic.es
Instituto de Química Médica (IQM)
Consejo Superior de Investigaciones Científicas (CSIC)
Madrid, Spain